000			01819nam a22002297a 4500
003			OSt
005			20241112124334.0
008			241112b |||||||| |||| 00| 0 eng d
020			_a1860941532
020			_a9781860941535
040			_cECOPH
100			_4Everitt, Brian.
245			_aStatistical aspects of the design and analysis of clinical trials / _c Brian S. Everitt, Andrew Pickles.
260			_aLondon ; River Edge, NJ : _b Imperial College Press ; Distributed by World Scientific Pub. Co., _c1999.
300			_axiv, 336 pages : _b illustrations
504			_aIncludes bibliographical references (pages 311-331) and index.
505			_aAn introduction to clinical trials -- Treatment allocation, the size of trials and reporting results -- Monitoring trial progress: outcome measures, compliance, dropouts and interim analyses -- Basic analyses of clinical trials, the generalized linear model and the economic evaluation of trials -- Simple approaches to the analysis of longitudinal data from clinical trials -- Multivariate normal regression models for longitudinal data from clinical trials -- Models for non-normal longitudinal data from clinical trials -- Survival analysis -- Bayesian methods -- Meta-analysis.
520			_aAbout 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. Correct interpretation of the data from such trials depends largely on adequate design and on performing the appropriate statistical analyses. In this book, the statistical aspects of both the design and analysis of trials are described, with particular emphasis on recently developed methods of analysis.
650			_vClinical trials - Statistical methods. _xStatistics - methods
700			_aPickles, Andrew.
942			_2lcc _cBook
999			_c424 _d424